propiverine hydrochloride

Treatment of urinary frequency, urgency and incontinenceNeurogenic bladder instability

15 mg 2–4 times a dayXL: 30 mg once daily

Molecular weight :403.9

%Protein binding :90–95

%Excreted unchanged in urine : <1

Volume of distribution (L/kg) :125–473 litres (Average: 279 litres)

half-life – normal/ESRD (hrs) :20

30–50 Dose as in normal renal function10–30 Dose as in normal renal function. Maximum 30 mg daily

<10 : Dose as in normal renal function. Maximum 30 mg daily

CAPD :Unknown dialysability. Dose as in GFR <10 mL/min

HD :Unknown dialysability. Dose as in GFR <10 mL/min

HDF/high flux :Unknown dialysability. Dose as in GFR <10 mL/min

CAV/VVHD :Unknown dialysability. Dose as in GFR 10 to 20 mL/min

Potentially hazardous interactions with other drugs

None known

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Oral

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